Related Experiment Video

Updated: May 17, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
05:14

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

Newborn with dilated cardiomyopathy secondary to vitamin d deficiency

Hanan Al Azkawi1, Angham Al Mutair

  • 1Pediatric Endocrinology Division, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

Case Reports in Pediatrics
|October 12, 2012
PubMed

Insights

Hypocalcemia, often caused by vitamin D deficiency, can lead to reversible dilated cardiomyopathy in newborns. Prompt calcium and vitamin D treatment rapidly restored the infant's cardiac function in this reported case.

Area of Science:

  • Pediatric Cardiology
  • Neonatology
  • Endocrinology

Background:

  • Hypocalcemia is an uncommon yet reversible cause of dilated cardiomyopathy.
  • Vitamin D deficiency is the primary etiological factor in most reported hypocalcemia cases.

Purpose of the Study:

  • To report a case of a newborn with hypocalcemia-induced dilated cardiomyopathy.
  • To highlight the role of vitamin D deficiency in this condition.
  • To demonstrate the efficacy of prompt treatment.

Main Methods:

  • Case report of a newborn presenting with symptoms of hypocalcemia and dilated cardiomyopathy.
  • Diagnostic workup to confirm low calcium levels and vitamin D deficiency.
  • Therapeutic intervention with calcium and vitamin D supplementation.

Main Results:

  • The newborn exhibited dilated cardiomyopathy secondary to severe hypocalcemia.
  • Biochemical tests confirmed vitamin D deficiency as the underlying cause.
  • Following treatment with calcium and vitamin D, rapid improvement in cardiac function was observed.

Conclusions:

  • Vitamin D deficiency-induced hypocalcemia can cause reversible dilated cardiomyopathy in neonates.
  • Early diagnosis and treatment are crucial for favorable cardiac outcomes.
  • This case underscores the importance of considering metabolic causes for cardiomyopathy in newborns.

More Related Videos

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System07:34

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System

Published on: May 5, 2018

Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration07:48

Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration

Published on: May 24, 2016

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Cardiomyopathy VI: Nursing Management01:29

Cardiomyopathy VI: Nursing Management

Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...