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Updated: May 17, 2026
09:11
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
Published on: February 13, 2016
Development of starch-gelatin complex microspheres as sustained release delivery system.
B N Vedha Hari1, T Praneetha, T Prathyusha
1Department of Pharmacy, SCBT, SASTRA University, Thirumalaisamudram, Thanjavur, Tamil Nadu, India.
Journal of Advanced Pharmaceutical Technology & Research
|October 12, 2012
Summary
Jackfruit seed starch and gelatin were used to create microspheres for drug delivery. These novel microspheres demonstrated excellent drug release properties and met pharmacopeial standards.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Natural polymers offer sustainable alternatives for drug delivery systems.
- Jackfruit seed starch presents an underutilized source for biomaterial development.
Purpose of the Study:
- To isolate and characterize jackfruit seed starch.
- To develop and evaluate jackfruit seed starch-gelatin microspheres for drug delivery.
Main Methods:
- Starch isolation and preformulation testing (density, particle size).
- Fourier Transform Infrared (FTIR) analysis for property confirmation.
- Ionotropic gelation technique for microsphere preparation with gelatin.
- Microsphere characterization (particle size, drug content, entrapment efficiency, yield).
- Scanning Electron Microscopy (SEM) for morphology.
- In vitro drug release studies and kinetic modeling.
Main Results:
- Jackfruit seed starch exhibited suitable preformulation properties.
- FTIR analysis confirmed starch identity and compatibility.
- Microspheres showed spherical morphology and high drug entrapment.
- In vitro drug release ranged from 89% to 100% over 12 hours.
- Kinetic modeling indicated a favorable drug release mechanism.
Conclusions:
- Jackfruit seed starch-gelatin microspheres are a viable and effective drug delivery system.
- The developed microspheres meet pharmacopeial requirements for drug delivery applications.
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