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Two brothers with idiopathic membranous nephropathy and familial sensorineural deafness
1Unita Operativa di Nefrologia e Dialisi, Ospedale di Vimercate, Università degli Studi, Milano, Italy.
Abstract:
Genetic factors could play an important role in the pathogenesis of idiopathic membranous nephropathy, and a few cases of familial membranous nephropathy have been described: an increased incidence of some HLA antigens as DR3 and others has been reported. We present two brothers with idiopathic membranous nephropathy and sensorineural deafness. HLA typing was performed in the two patients and in the members of the family, and it showed the absence of linkage of an HLA antigen with the renal disease in the family.
Insights
Familial idiopathic membranous nephropathy (IMN) with sensorineural deafness is rare. This study examined two brothers with IMN and deafness, finding no HLA antigen linkage to the renal disease in their family.
Area of Science:
- Nephrology
- Genetics
- Otolaryngology
Background:
- Idiopathic membranous nephropathy (IMN) is a leading cause of nephrotic syndrome in adults.
- Genetic factors are implicated in IMN pathogenesis, with some studies suggesting associations with Human Leukocyte Antigen (HLA) types.
- Familial cases of IMN are infrequently reported, sometimes co-occurring with other conditions.