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Related Concept Videos

Overview Of Cell Separation And Isolation01:20

Overview Of Cell Separation And Isolation

Cell separation was first achieved in 1964 by S. H. Seal, who separated large tumor cells from the smaller blood cells using filtration. Two years later, Pohl and Hawk performed experiments on how cells respond differently to a nonuniform electric field based on the cell type. Such observations were the inception of cell separation methods, which allow isolating a single cell type from a heterogeneous sample.

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Related Experiment Video

Updated: May 17, 2026

Systematic Analysis of In Vitro Cell Rolling Using a Multi-well Plate Microfluidic System
11:04

Systematic Analysis of In Vitro Cell Rolling Using a Multi-well Plate Microfluidic System

Published on: October 16, 2013

Bioengineering methods for analysis of cells in vitro.

Gregory H Underhill1, Peter Galie, Christopher S Chen

  • 1Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Annual Review of Cell and Developmental Biology
|October 13, 2012
PubMed
Summary
This summary is machine-generated.

Bioengineering innovations enable precise control and measurement of cell-environmental interactions in vitro. These advanced tools and biomaterials offer new insights into cellular responses for biological studies and therapies.

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Area of Science:

  • Bioengineering
  • Cellular Biology
  • Biomaterials Science

Background:

  • Investigating complex cell responses in vitro is challenging.
  • Understanding cellular microenvironments requires dissecting individual signals.
  • Previous methods lacked precise control over cellular stimuli.

Purpose of the Study:

  • To review bioengineering approaches for controlling and measuring cell-environmental interactions in vitro.
  • To highlight the role of microtechnology and biomaterials.
  • To discuss mechanistic insights and applications.

Main Methods:

  • Utilizing microtechnology for controlled presentation of environmental cues.
  • Employing advanced biomaterials to mimic in vivo conditions.
  • Implementing high-throughput analysis strategies for systematic study.

Main Results:

  • Development of innovative methods for in vitro cell investigation.
  • Ability to reduce complex microenvironments into distinct signals.
  • Gained mechanistic insights into cell-environmental interactions.

Conclusions:

  • Bioengineering tools are crucial for understanding cellular behavior.
  • Applications span fundamental research, in vitro modeling, and cell-based therapies.
  • Advances facilitate better construction of in vivo mimics and deconstruction for study.