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Updated: May 17, 2026

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
06:39

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Published on: August 19, 2020

Focal epithelial hyperplasia - an update.

Ahmed K Said1, Jair C Leao, Stefano Fedele

  • 1Oral Medicine Unit, UCL Eastman Dental Institute, London, UK.

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
|October 16, 2012
PubMed
Summary
This summary is machine-generated.

Focal epithelial hyperplasia (FEH) is a benign oral condition often seen in children and adolescents, frequently linked to human papillomavirus (HPV). While typically asymptomatic, treatment may be needed for cosmetic or functional reasons.

Keywords:
HPVfocalhyperplasiamucosaoral

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Area of Science:

  • Oral Pathology
  • Dermatology
  • Infectious Diseases

Background:

  • Focal epithelial hyperplasia (FEH) is a benign mucosal condition primarily affecting children and adolescents in specific regions.
  • It is often associated with poverty and low socioeconomic status.
  • The condition presents as painless papules, plaques, or nodules that may merge.

Purpose of the Study:

  • To review the characteristics, associations, and management of Focal epithelial hyperplasia.
  • To highlight the role of human papillomavirus (HPV) in FEH etiology.
  • To discuss diagnostic methods and therapeutic options for FEH.

Main Methods:

  • Review of clinical and histopathological features of FEH.
  • Association studies linking HPV genotypes (13 and 32) to FEH lesions.
  • Discussion of diagnostic approaches including clinical examination and biopsy.
  • Analysis of treatment outcomes and efficacy of various interventions.

Main Results:

  • Human papillomavirus (HPV), particularly genotypes 13 and 32, is detected in most FEH lesions.
  • Diagnosis is often based on clinical presentation and social history, with histopathology for confirmation.
  • Spontaneous resolution occurs, but aesthetic or occlusal concerns may necessitate treatment.

Conclusions:

  • FEH is a benign condition with no evidence of malignant potential.
  • Management strategies include surgical removal, laser excision, or topical antivirals.
  • Further research into specific therapies for FEH may be beneficial.