Commonly encountered dilemmas in breast cancer reporting and staging

Treatment modalities for common malignancies such as breast carcinoma have become increasingly complex, necessitating more rigorous documentation by pathologists of the histopathologic features required for staging and therapy. In 2009 the American Joint Committee on Cancer published the most recent update to its Cancer Staging Manual, the most salient points of which are readily available on the College of American Pathologists' Web site. Based on these guidelines, herein we summarize some of the more commonly encountered dilemmas in breast cancer reporting, with emphasis on tumor size, lymph node status, determination of mitotic count for tumor grade, and skin/chest wall involvement (pathologic stage T4).