Related Experiment Video
Updated: May 17, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Low-flow, low-gradient aortic stenosis with normal and depressed left ventricular ejection fraction.
Philippe Pibarot1, Jean G Dumesnil
1Québec Heart & Lung Institute, Department of Medicine, Laval University, Québec City, Québec, Canada. philippe.pibarot@med.ulaval.ca
Diagnosing low-flow, low-gradient aortic stenosis (AS) is challenging, especially when left ventricular ejection fraction (LVEF) is normal. This review covers diagnostic and therapeutic strategies for low-flow, low-gradient AS in patients with and without depressed LVEF.
Area of Science:
- Cardiology
- Valvular Heart Disease
- Echocardiography
Background:
- Low-flow, low-gradient (LF-LG) aortic stenosis (AS) presents diagnostic challenges, particularly with depressed or preserved left ventricular ejection fraction (LVEF).
- Reduced transvalvular flow complicates the assessment of AS severity in both scenarios.
- Distinguishing true severe AS from pseudosevere stenosis and assessing myocardial function are critical in patients with depressed LVEF.
Related Concept Videos
Mitral Stenosis I: Introduction
Mitral Stenosis II: Clinical features and Diagnostic Tests
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Mitral Stenosis IV: Nursing Management
Aortic Regurgitation I: Introduction
Aortic Regurgitation III: Medical Management

