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Related Concept Videos

Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Updated: May 17, 2026

Immunohistochemical Staining of B7-H1 (PD-L1) on Paraffin-embedded Slides of Pancreatic Adenocarcinoma Tissue
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Immunohistochemical Staining of B7-H1 (PD-L1) on Paraffin-embedded Slides of Pancreatic Adenocarcinoma Tissue

Published on: January 3, 2013

Mannan-binding lectin in malignancy.

Anna S Swierzko1, David C Kilpatrick, Maciej Cedzynski

  • 1Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland.

Molecular Immunology
|October 16, 2012
PubMed
Summary
This summary is machine-generated.

Mannan-binding lectin (MBL) may influence cancer development or inhibition. Understanding MBL

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Immunohistochemical Staining of B7-H1 (PD-L1) on Paraffin-embedded Slides of Pancreatic Adenocarcinoma Tissue
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Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology
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Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology

Published on: March 24, 2015

Area of Science:

  • Immunology
  • Oncology
  • Complement System Biology

Background:

  • The complement system plays a complex role in cancer, potentially promoting or inhibiting tumor growth.
  • Complement components are being investigated as biomarkers for cancer detection, progression, and therapy response.
  • Complement deficiencies can heighten infection risk and mortality, particularly in chemotherapy patients.

Purpose of the Study:

  • To discuss the potential associations between mannan-binding lectin (MBL) and cancer.
  • To explore MBL's role as a factor activating the complement lectin pathway in the context of cancer.

Main Methods:

  • Literature review and discussion of existing research on MBL and cancer.
  • Analysis of MBL's function within the complement lectin pathway.
  • Exploration of MBL's dual role in tumor development and inhibition.

Main Results:

  • Mannan-binding lectin (MBL) may have a dual role in cancer, influencing both tumor development and inhibition.
  • MBL's involvement in the complement lectin pathway suggests its potential impact on cancer progression.
  • Deficiencies in complement factors, potentially including MBL, are linked to increased infection risks and mortality.

Conclusions:

  • MBL's multifaceted role in the complement system warrants further investigation in cancer research.
  • Understanding MBL's contribution to cancer could lead to novel diagnostic or therapeutic strategies.
  • Further studies are needed to elucidate the precise mechanisms by which MBL affects cancer.