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Updated: May 17, 2026

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
Published on: June 24, 2021
SPLOOCE: a new portal for the analysis of human splicing variants
José Eduardo Kroll1, Pedro A F Galante, Daniel T Ohara
1Laboratory of Computational Biology, Ludwig Institute for Cancer Research; São Paulo, Brazil; Inter-institutional Program on Bioinformatics, University of São Paulo, São Paulo, Brazil.
Abstract:
Understanding alternative splicing is crucial to elucidate the mechanisms behind several biological phenomena, including diseases. The huge amount of expressed sequences available nowadays represents an opportunity and a challenge to catalog and display alternative splicing events (ASEs). Although several groups have faced this challenge with relative success, we still lack a computational tool that uses a simple and straightforward method to retrieve, name and present ASEs. Here we present SPLOOCE, a portal for the analysis of human splicing variants. SPLOOCE uses a method based on regular expressions for retrieval of ASEs. We propose a simple syntax that is able to capture the complexity of ASEs.
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