Related Experiment Video
Updated: May 17, 2026
11:30
A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
Bone disease in pediatric chronic kidney disease
1Department of Pediatrics, David Geffen School of Medicine at UCLA, A2-383 MDCC, 650 Charles Young Drive, Los Angeles, CA, 90095, USA. kwesseling@mednet.ucla.edu
Pediatric Nephrology (Berlin, Germany)
|October 16, 2012
Summary
Children with chronic kidney disease (CKD) often have bone disease, leading to disability. New research highlights the importance of assessing bone turnover, mineralization, and volume (TMV) for a better understanding of renal osteodystrophy (ROD) progression in CKD.
Area of Science:
- Nephrology
- Pediatric Nephrology
- Bone Metabolism
Background:
- Children with chronic kidney disease (CKD) exhibit significant bone disease, including deformities and fractures, causing long-term disability.
- Skeletal mineralization abnormalities are prevalent in pediatric CKD patients, contributing to chronic morbidity.
Purpose of the Study:
- To explore the progression of renal osteodystrophy (ROD) in chronic kidney disease (CKD).
- To investigate the cell biology alterations associated with ROD.
- To emphasize the importance of assessing bone turnover (T), mineralization (M), and volume (V) (TMV) in CKD bone disease.
Main Methods:
- Review of recent data on ROD progression in CKD.
- Analysis of cell biology alterations accompanying ROD.
- Discussion of the TMV classification for ROD assessment.
Main Results:
- Recent data provide insights into the progression of renal osteodystrophy (ROD) throughout the course of chronic kidney disease (CKD).
- Alterations in cell biology accompanying ROD have been elucidated.
- The limitations of assessing ROD due to the infrequent use of bone biopsy are highlighted.
Conclusions:
- A comprehensive understanding of ROD progression and its impact on bone health in CKD is crucial.
- The TMV assessment framework offers a standardized approach to evaluating bone disease in CKD patients.
- Further research is needed to overcome the limitations of bone biopsy and improve ROD management.
Related Concept Videos
01:24Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
01:25Chronic Kidney Disease I: Introduction
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
01:28Chronic Kidney Disease III: Interprofessional Care
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:18Chronic Kidney Disease IV: Nursing Management
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...
01:02What is the Skeletal System?
Overview