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Prognostic implications of plasma myoglobin levels in patients with chronic kidney disease

Aurélie Lenglet1, Sophie Liabeuf, Lucie Desjardins

  • 1French National Institute of Health and Medical Research-INSERM, ERI-12-EA 4292, Amiens, France.

The International Journal of Artificial Organs
|October 16, 2012
PubMed

Insights

Plasma myoglobin (Mb) is elevated in chronic kidney disease (CKD) patients. However, this study found no significant association between higher Mb levels and adverse cardiovascular or renal outcomes in CKD patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Biomarker Discovery

Background:

  • Chronic kidney disease (CKD) is associated with poor cardiovascular outcomes.
  • There is a need for improved biomarkers to stratify risk in CKD patients.
  • Plasma myoglobin (Mb) has been investigated as a potential biomarker.

Purpose of the Study:

  • To evaluate plasma myoglobin (Mb) levels across different stages of chronic kidney disease (CKD).
  • To determine the association of plasma Mb levels with overall mortality, cardiovascular (CV) mortality, CV events, and renal outcomes in CKD patients.

Main Methods:

  • Plasma Mb levels were measured in 140 CKD patients and 27 healthy controls.
  • Patients were prospectively monitored for mortality, CV events, and CKD progression.
  • Statistical analyses, including multivariate analysis, were performed to assess associations.

Main Results:

  • Plasma Mb levels were higher in CKD patients than controls and increased with declining glomerular filtration rate.
  • CKD stage was the only independent predictor of plasma Mb levels in multivariate analysis.
  • While crude analysis suggested Mb predicted mortality and CV events, this association was lost after adjustment for other factors. Mb did not predict CKD progression.

Conclusions:

  • Plasma Mb levels are elevated in CKD patients compared to healthy individuals.
  • No significant clinical outcome (mortality, CV events, renal outcomes) was associated with elevated plasma Mb in this study.
  • Larger studies are required to validate these findings.
Abstract

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