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[Detection of weak graft-versus-host reactions by the suppressive effect on the immune response (author's transl)]
Weak graft-versus-host reactions induced between H-2 compatible strains are not detected by the splenomegaly assay in newborn mice. Similarly the proliferative response in the mixed lymphocyte culture or the popliteal lymph node assay was not extensive in some combinations. On the contrary, the inhibition of the specific immune response to heterologous red cells was observed when graft occurred from 15 days before immunization. So the weak graft-versus-host reactions appeared to be easily detected by the suppressive effect on antibody synthesis.
Weak graft-versus-host reactions induced between H-2 compatible strains are not detected by the splenomegaly assay in newborn mice. Similarly the proliferative response in the mixed lymphocyte culture or the popliteal lymph node assay was not extensive in some combinations. On the contrary, the inhibition of the specific immune response to heterologous red cells was observed when graft occurred from 15 days before immunization. So the weak graft-versus-host reactions appeared to be easily detected by the suppressive effect on antibody synthesis.