Preparation, optimization and characterization of multiple unit microspheres containing kollidone SR

Area of Science:

• Pharmaceutical Technology
• Drug Delivery Systems
• Materials Science

Background:

• Hydrochlorothiazide is a widely used diuretic.
• Developing effective drug delivery systems is crucial for improving therapeutic outcomes.
• Floating microspheres offer potential for prolonged drug release and enhanced bioavailability.

Purpose of the Study:

• To investigate the impact of viscosity and drug-polymer ratio on Hydrochlorothiazide release from floating microspheres.
• To optimize the formulation of Hydrochlorothiazide-loaded floating microspheres.
• To evaluate the physicochemical and drug release properties of the prepared microspheres.

Main Methods:

• Floating microspheres loaded with Hydrochlorothiazide were prepared using the emulsion solvent evaporation technique.
• Microsphere characterization included micromeritics, drug entrapment efficiency, and floating ability assessment.
• In vitro drug release studies were conducted to evaluate the release kinetics.

Main Results:

• Viscosity and drug-polymer ratio significantly influenced Hydrochlorothiazide release.
• Optimized formulations demonstrated good floating ability and high drug entrapment efficiency.
• The release profile of Hydrochlorothiazide was found to be dependent on the formulation parameters.

Conclusions:

• The study successfully demonstrated the influence of viscosity and drug-polymer ratio on Hydrochlorothiazide release from floating microspheres.
• Emulsion solvent evaporation is a viable method for preparing Hydrochlorothiazide-loaded floating microspheres.
• The findings provide valuable insights for the design of controlled-release formulations for Hydrochlorothiazide.