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From basic biology to randomized clinical trial: the Beta Radiation for Arteriovenous Graft Outflow Stenosis (BRAVO
Prabir Roy-Chaudhury1, Perry Arnold, Jeff Seigel
1Dialysis Vascular Research Group, Division of Nephrology, University of Cincinnati and VA Medical Center, Cincinnati, Ohio, USA. prabir.roychaudhury@uc.edu
Abstract:
The BRAVO-II study was a randomized controlled study of endovascular radiation therapy as compared to sham radiation therapy, following angioplasty of a thrombosed PRFE graft. The results did not show a benefit of endovascular radiation therapy, albeit in the context of an early termination of the study at less than 50% enrollment due to business reasons. Emphasis is laid on the fact that there may still be a role for radiation therapy in specific clinical settings associated with dialysis vascular access dysfunction.
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