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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
Fungal Group Zygomycota01:29

Fungal Group Zygomycota

Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
Fungal Phylum Basidiomycota01:26

Fungal Phylum Basidiomycota

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Studying Cryptosporidium Infection in 3D Tissue-derived Human Organoid Culture Systems by Microinjection
05:31

Studying Cryptosporidium Infection in 3D Tissue-derived Human Organoid Culture Systems by Microinjection

Published on: September 14, 2019

Coccidioidomycosis.

Oliverio Welsh1, Lucio Vera-Cabrera, Adrian Rendon

  • 1Department of Dermatology, Dr. Jose E. Gonzalez University Hospital, Universidad Autónoma de Nuevo León, Ave Madero y Ave Gonzalitos s/n, Colonia Mitras Centro, Monterrey, Nuevo Leon, 64460, México. owelsh@yahoo.com

Clinics in Dermatology
|October 17, 2012
PubMed
Summary
This summary is machine-generated.

Coccidioidomycosis, a fungal infection prevalent in arid American regions, typically causes asymptomatic illness. Disseminated disease is rare, but immunocompromised individuals and pregnant women need careful management and treatment.

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Last Updated: May 17, 2026

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05:31

Studying Cryptosporidium Infection in 3D Tissue-derived Human Organoid Culture Systems by Microinjection

Published on: September 14, 2019

Area of Science:

  • Mycology
  • Infectious Diseases
  • Epidemiology

Background:

  • Coccidioidomycosis is a systemic fungal infection caused by *Coccidioides immitis* and *Coccidioides posadasii*.
  • The fungi are endemic to arid regions of the Americas, particularly the Southwestern United States and Northern Mexico.
  • While most infections are asymptomatic, a small percentage of individuals develop disseminated disease.

Purpose of the Study:

  • To provide an overview of coccidioidomycosis, including its causative agents, geographic distribution, clinical presentation, and diagnostic methods.
  • To highlight the importance of considering prognostic factors and special populations, such as immunocompromised patients and pregnant women.
  • To review current and alternative therapeutic strategies for managing coccidioidomycosis.

Main Methods:

  • Fungal identification relies on culture, biopsy, and DNA probes.
  • Prognosis is influenced by antibody detection and skin test reactivity.
  • Treatment options include azole antifungals and amphotericin B.

Main Results:

  • Most cases of coccidioidomycosis remain asymptomatic.
  • Disseminated disease occurs in less than 5% of symptomatic patients.
  • Effective treatments include amphotericin B, itraconazole, and fluconazole, with posaconazole and voriconazole for refractory cases.

Conclusions:

  • Coccidioidomycosis diagnosis and management require careful consideration of patient factors and disease severity.
  • Early identification and appropriate antifungal therapy are crucial for favorable outcomes.
  • Special attention is necessary for immunocompromised individuals and pregnant women due to increased risk and potential complications.