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Updated: May 17, 2026

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
08:48

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

Paracoccidioidomycosis.

Sílvio Alencar Marques1

  • 1Department of Dermatology and Radiotherapy, Botucatu Medical School, São Paulo State University (UNESP), Rua Costa Leite 515, 18600-010, Botucatu, São Paulo, Brazil. marques@fmb.unsep.br

Clinics in Dermatology
|October 17, 2012
PubMed
Summary
This summary is machine-generated.

Paracoccidioidomycosis is a fungal infection endemic to Latin America, primarily affecting the lungs. Early diagnosis through microscopy and culture, alongside appropriate antifungal treatment, is crucial for managing this systemic mycosis.

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Last Updated: May 17, 2026

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
08:48

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

Area of Science:

  • Mycology
  • Infectious Diseases
  • Epidemiology

Background:

  • Paracoccidioidomycosis is an endemic systemic mycosis prevalent in Latin America.
  • It is caused by a dimorphic fungus acquired through inhalation, leading to dissemination from the lungs.
  • Clinical presentations vary, necessitating differentiation from other serious conditions like tuberculosis and cancer.

Purpose of the Study:

  • To provide an overview of paracoccidioidomycosis, including its epidemiology, clinical features, diagnosis, and treatment.
  • To highlight the importance of distinguishing paracoccidioidomycosis from other diseases with similar manifestations.
  • To outline current therapeutic strategies for different forms of the disease.

Main Methods:

  • Diagnosis relies on identifying the causative fungus in biopsy specimens.
  • Fungal culture is essential for confirming the presence of the organism.
  • Clinical presentation and patient history guide diagnostic and therapeutic decisions.

Main Results:

  • The fungus disseminates from the lungs, causing diverse clinical manifestations.
  • Differential diagnosis is critical, involving conditions such as tuberculosis, Hodgkin disease, other mycoses, and squamous cell carcinoma.
  • Treatment varies by severity, ranging from sulfamethoxazole-trimethoprim for mild cases to amphotericin B for severe disease.

Conclusions:

  • Paracoccidioidomycosis requires prompt and accurate diagnosis for effective management.
  • Appropriate antifungal therapy, tailored to disease severity and specific manifestations (including meningeal involvement), is key to successful outcomes.
  • Understanding the epidemiological and clinical spectrum of this mycosis is vital for healthcare providers in endemic regions.