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Related Concept Videos

Assumptions of Survival Analysis01:15

Assumptions of Survival Analysis

Survival models analyze the time until one or more events occur, such as death in biological organisms or failure in mechanical systems. These models are widely used across fields like medicine, biology, engineering, and public health to study time-to-event phenomena. To ensure accurate results, survival analysis relies on key assumptions and careful study design.
Kaplan-Meier Approach01:24

Kaplan-Meier Approach

The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...
Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least squares (OLS)...
Strategies for Assessing and Addressing Confounding01:25

Strategies for Assessing and Addressing Confounding

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Bias in Epidemiological Studies01:29

Bias in Epidemiological Studies

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Confounding in Epidemiological Studies01:27

Confounding in Epidemiological Studies

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Related Experiment Video

Updated: May 17, 2026

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

Case-mix adjusted hospital mortality is a poor proxy for preventable mortality: a modelling study.

Alan J Girling1, Timothy P Hofer, Jianhua Wu

  • 1Department of Public Health, Epidemiology and Biostatistics, University of Birmingham, Birmingham, UK.

BMJ Quality & Safety
|October 17, 2012
PubMed
Summary

Standardized mortality ratios (SMRs) may not accurately reflect preventable hospital deaths. Our model shows SMRs are highly sensitive to the actual proportion of preventable deaths, impacting hospital performance assessments.

Related Experiment Videos

Last Updated: May 17, 2026

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

Area of Science:

  • Healthcare quality and safety
  • Health services research
  • Medical statistics

Background:

  • Risk-adjustment schemes are crucial for monitoring hospital performance.
  • These schemes assume unexplained excess mortality indicates suboptimal care.
  • Standardized mortality ratios (SMRs) are commonly used metrics.

Purpose of the Study:

  • To develop a model estimating the proportion of SMR variation attributable to preventable mortality.
  • To assess the predictive value of SMRs for identifying hospitals with high preventable mortality rates.
  • To provide a 'reality check' for existing case-mix adjustment methodologies.

Main Methods:

  • Developed a statistical model to quantify the relationship between SMRs and preventable mortality.
  • Utilized literature values to populate the model and estimate predictive values.
  • Calculated the proportion of hospitals in the highest SMR percentile that also fall in the worst preventable mortality percentile.

Main Results:

  • The predictive value of SMRs is highly sensitive to the underlying proportion of preventable deaths.
  • If 6% of hospital deaths are preventable, SMRs predict preventable mortality with only 9% accuracy.
  • This predictive value can increase to 30% if 15% of deaths are preventable.

Conclusions:

  • Current risk-adjustment schemes using SMRs may misattribute preventable deaths.
  • The accuracy of SMRs in reflecting true hospital performance is contingent on the true rate of preventable mortality.
  • The developed model highlights the limitations of SMRs and suggests caution in their interpretation for quality assessment.