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Published on: January 19, 2019
Comparison of immunological properties of various bioactive combinations
Vaclav Vetvicka1, Jana Vetvickova
1Department of Pathology, University of Louisville, Louisville, KY, USA. Vaclav.vetvicka@louisville.edu
Background:
Lately, more and more preparation of various cocktails or mixtures of bioactive modulators have been introduced. Their true activity is, however, rarely tested.
Aim:
To compare six commercially available, glucan-based immunostimulators.
Methods:
Immunological effects of tested combinations were measured by evaluation of phagocytosis of synthetic particles by peripheral blood neutrophils, production of IL-2 by mouse splenocytes, production of superoxide anion and nitrite oxide, antibody response to imunization with ovalbumin, and NK cell activity.
Results:
Our results showed that with the exception of the highest doses (phagocytosis) and superoxide anion and nitrite oxide production, only RVB 300 showed significant immunostimulative activity.
Conclusion:
Based on our results, we can conclude that most of the tested natural immunomodulators have limited, if any, biological effects. Only RVB 300 significantly stimulated all six tested immunological reactions.
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