Related Experiment Video
Updated: May 17, 2026

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
Investigations regarding the utility of prodigiosenes to treat leukemia
Deborah A Smithen1, A Michael Forrester, Dale P Corkery
1Department of Chemistry, Dalhousie University, Halifax, Nova Scotia B4P 2R6, Canada.
Abstract:
Prodigiosenes, possessing a 4-methoxypyrrolyldipyrrin skeleton, are known for their anti-cancer activity. Structural modification of the C-ring resulted in a series of prodigiosenes that displayed promising activity against leukemia cell lines during in vitro analysis against the NCI 60 cancer cell line panel. Further in vivo studies of these compounds using the zebrafish model showed persistence of anti-leukemia properties in human K562 chronic myelogenous leukemia cells.

