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Updated: Oct 16, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Iodine-mediated desulfurative cyclization to trifunctionalized pyrido[1,2-b]indazoles
Jun Ma1, Si-Yu Song1, Li-Sheng Wang1
1State Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China.
Abstract:
While thioamides are widely utilized as nucleophilic or ambiphilic synthons to construct heterocycles, strategies harnessing their inherent electrophilic reactivity to form carbon-heteroatom bonds through desulfurization with intact amino groups reserved for downstream cyclization are scarcely documented. Herein, we report a metal-free I2-DMSO-mediated tandem cyclization protocol that exploits the underexplored electrophilic nature of thioamides for facile one-pot assembly of trifunctionalized pyrido[1,2-b]indazoles. Moreover, further derivatization of these products furnishes 1-imino-3-phenyl-1H,3H-furo[3',4':4,5]pyrimido[1,2-b]indazol-11-amine, an unprecedented fused polycyclic scaffold.
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