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Relation between red cell distribution width and severity of coronary artery disease in patients with acute

Fatih Akin1, Nuri Köse, Burak Ayça

  • 11Department of Cardiology, Muğla Sıtkı Kocman University School of Medicine, Muğla, Turkey.

Angiology
|October 17, 2012
PubMed

Insights

Red blood cell distribution width (RDW) is linked to more severe coronary artery disease (CAD) in acute myocardial infarction (AMI) patients. Higher RDW independently predicts CAD severity, offering a simple marker for risk assessment.

Area of Science:

  • Cardiology
  • Hematology
  • Laboratory Medicine

Background:

  • Elevated red blood cell distribution width (RDW) is associated with adverse outcomes in acute myocardial infarction (AMI).
  • The relationship between RDW and the severity of coronary artery disease (CAD) in AMI patients requires further elucidation.

Purpose of the Study:

  • To investigate the association between RDW and the angiographic severity of CAD in patients presenting with AMI.
  • To determine if RDW is an independent predictor of CAD severity in this population.

Main Methods:

  • Retrospective analysis of 580 patients with AMI undergoing coronary angiography.
  • Correlation analysis between RDW, neutrophil/lymphocyte (N/L) ratio, and Syntax Score (SS).
  • Multiple logistic regression to identify independent predictors of CAD severity.

Main Results:

  • Patients with high Syntax Scores (SS >32) exhibited significantly higher RDW values (15.1% ± 1.7% vs 14.1 ± 1.7%, P < .001).
  • RDW showed a positive correlation with both SS (r = .252, P < .001) and N/L ratio (r = .178, P < .001).
  • RDW was identified as an independent predictor of CAD severity (odds ratio = 1.165, P = .021).

Conclusions:

  • RDW is independently associated with the severity of coronary artery disease in patients with acute myocardial infarction.
  • RDW is an inexpensive and easily measurable laboratory marker that can aid in assessing CAD severity in AMI patients.

Keywords:
acute myocardial infarctionneutrophils/lymphocytes ratiored blood cell distribution widthsyntax score

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