Related Experiment Video
Updated: May 17, 2026
07:07
Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
A cationic gold complex cleaves BArF24
Simone G Weber1, David Zahner, Frank Rominger
1Universität Heidelberg, INF 270, D-69120 Heidelberg, Germany.
Chemical Communications (Cambridge, England)
|October 18, 2012
Summary
A novel gold complex, IPr**Au-BArF(24), acts as a "soft proton" to activate C-B bonds. This sterically shielded complex enables efficient C-B bond cleavage at room temperature without solvent coordination.
Area of Science:
- Organometallic Chemistry
- Catalysis
- Inorganic Chemistry
Background:
- Sterically hindered N-heterocyclic carbene (NHC) gold complexes are valuable catalysts.
- Activation of weakly coordinating counterions is crucial for catalytic processes.
- Understanding the reactivity of monovalent transition metal electrophiles is key.
Purpose of the Study:
- To synthesize and characterize a sterically shielded cationic NHC gold complex.
- To investigate the in situ activation of a weakly coordinating counterion by the gold complex.
- To explore the potential of this complex as a "soft proton" equivalent.
Main Methods:
- In situ preparation of the gold complex IPr**Au-BArF(24) in dichloromethane.
- Spectroscopic characterization of the reaction intermediates.
- Analysis of the heterolytic C-B bond activation mechanism.
Main Results:
- The sterically shielded cationic NHC gold complex IPr**Au-BArF(24) was successfully prepared in situ.
- The complex demonstrated the ability to heterolytically activate the C-B bond of the tetrakis[3,5-bis(trifluoromethyl)phenyl]borate counterion.
- This activation occurred at room temperature without requiring solvent coordination, highlighting the complex's unique reactivity.
Conclusions:
- The synthesized gold complex functions as a "soft proton" due to its sterically shielded nature.
- Efficient C-B bond activation of weakly coordinating anions is achievable at room temperature.
- This study provides insights into the reactivity of monovalent transition metal electrophiles and their application in catalysis.
Related Concept Videos
01:20Immunogold Electron Microscopy
Immunoelectron microscopy utilizes immunogold labeling of endogenous proteins with specific antibodies to detect and localize these proteins in cells and tissues. The procedure provides insights into the distribution and quantification of protein under different stimulation conditions offering clues about their functions. Conjugating highly electron-dense gold particles with primary or secondary antibodies allow antigen detection on and within cells, with high resolution and specificity.
01:02Long-patch Base Excision Repair
Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
03:45Formation of Complex Ions
A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
01:57Protein Complexes with Interchangeable Parts
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...