CD226 Gly307Ser association with multiple autoimmune diseases: a meta-analysis

Area of Science:

• Genetics
• Immunology
• Molecular Biology

Background:

• Growing evidence links the CD226 gene polymorphism (Gly307Ser/rs763361) to various autoimmune diseases (ADs).
• Autoimmune diseases may share common pathogenic pathways, necessitating an overall assessment of this genetic link.

Purpose of the Study:

• To perform a meta-analysis assessing the overall relationship between the CD226 Gly307Ser (rs763361) polymorphism and multiple autoimmune diseases.
• To consolidate evidence regarding the association between rs763361 and susceptibility to ADs.

Main Methods:

• A systematic search of PubMed and Embase databases was conducted for eligible case-control studies.
• Crude odds ratios (OR) with 95% confidence intervals (CI) were calculated to evaluate the association.
• A random effects model was employed for the meta-analysis.

Main Results:

• The meta-analysis included 7 studies with 7876 cases and 8558 controls.
• A significant overall increased risk for ADs was associated with the T allele (OR=1.19, 95%CI=1.12-1.27).
• Significant associations were observed across South American, Asian, and European populations, and in codominant and recessive genetic models.

Conclusions:

• The CD226 Gly307Ser (rs763361) polymorphism is significantly associated with an increased risk of multiple autoimmune diseases.
• This finding supports a role for CD226 in the pathogenesis of a spectrum of autoimmune conditions.