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Updated: May 17, 2026
10:41
An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
Published on: April 5, 2018
[Epigenetics in tumorigenesis: advances and clinical implications]
Xian huo Wang1, Xiu juan Zhao, Li hua Qiu
1Department of Lymphoma, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Summary
Cancer is increasingly recognized as more than a genetic disease. Epigenetic regulation, particularly chromatin modifications, plays a crucial role in cancer development and offers new avenues for prevention and treatment.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Context:
- Cancer is a major global health challenge with rising incidence.
- Historically viewed as a genetic disease due to DNA alterations.
- Recent research emphasizes the significant role of epigenetic factors.
Purpose:
- To review advances in understanding epigenetic regulation in cancer.
- To explore the role of chromatin-based mechanisms in tumorigenesis.
- To discuss the implications for novel cancer strategies.
Summary:
- Epigenetic regulation, involving changes in gene expression without altering DNA sequence, is critical in cancer.
- Chromatin modifications are key players in the development and progression of various cancers.
- This review synthesizes current knowledge on epigenetics in cancer biology.
Impact:
- Highlights the importance of epigenetics beyond genetics in cancer.
- Informs the development of innovative strategies for cancer prevention.
- Provides insights for novel diagnostic and therapeutic approaches in oncology.
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
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When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
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01:46Epigenetic Regulation
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01:46Epigenetic Regulation
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