Related Experiment Video
Updated: May 17, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Obesity and hormonal contraception: safety and efficacy
Alison B Edelman1, Jeffrey T Jensen
1Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon 97239, USA. edelmana@ohsu.edu
Abstract:
The biological capacity for pregnancy complicates the impact of obesity on the health and well-being of women. Consequently, the ability to prevent or plan pregnancies through the use of contraception is critical for obese women. Unfortunately, contraception is often forgotten or feared in women with chronic medical problems like obesity. This review addresses the safety and efficacy of hormonal contraceptive methods in obese women. Generally, the risks of pregnancy outweigh the risks of hormonal contraception in an obese woman, but obesity is a significant risk factor for thrombosis, which should be taken into account when recommending a combined hormonal method. Limited data suggest that the efficacy of some hormonal methods may be reduced in obese women.
Related Concept Videos
Drug Dosing: Obese Patients
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
Obesity
Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
Hormonal Control of the Ovarian Cycle
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Birth Control Methods

