Related Experiment Video
Updated: May 17, 2026
06:11
Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection
Published on: May 17, 2024
Female obesity and assisted reproductive technologies
Banu Kumbak1, Engin Oral, Orhan Bukulmez
1IVF Unit, Department of Obstetrics and Gynecology, Fırat University Medical School, Elazig, Turkey.
Seminars in Reproductive Medicine
|October 18, 2012
Summary
Obesity negatively impacts fertility treatments, leading to poorer outcomes in women undergoing assisted reproductive technologies (ART). Further research is needed to understand these effects and guide treatment policies.
Area of Science:
- Reproductive Endocrinology
- Obesity Medicine
- Infertility Research
Background:
- Obesity is a global epidemic, affecting nearly half of reproductive-age women.
- Obese women undergoing assisted reproductive technologies (ART) exhibit unfavorable ovarian stimulation and reduced ART success rates.
- Increased body mass index is linked to lower pregnancy and live-birth rates and higher miscarriage rates.
Purpose of the Study:
- To investigate the impact of obesity on assisted reproductive technologies (ART) outcomes.
- To explore the association between body mass index (BMI) and fertility treatment success.
- To review maternal, perinatal, and neonatal complications in obese pregnancies.
Main Methods:
- Literature review of studies investigating obesity and ART.
- Analysis of data on ovarian stimulation, oocyte retrieval, and pregnancy rates in relation to BMI.
- Examination of factors such as age and polycystic ovary syndrome (PCOS) in obese women.
Main Results:
- Obese women show increased gonadotropin use, fewer follicles, and lower oocyte yield during ART.
- Higher BMI correlates with reduced pregnancy and live-birth rates and increased miscarriage.
- Maternal, perinatal, and neonatal complications are elevated in obese pregnancies.
Conclusions:
- Obesity presents significant challenges for fertility treatments and pregnancy outcomes.
- The underlying mechanisms of adverse effects in obese women require further elucidation.
- Ethical and social considerations surrounding fertility treatment access for obese women are debated, with a need for patient counseling on weight management.
More Related Videos
Related Concept Videos
01:28Infertility in Females
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...
Endometriosis, a condition characterized by abnormal growth of endometrial...
01:23Infertility in Males
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
01:25Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
01:24Obesity
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
01:21Drug Dosing: Obese Patients
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
01:20Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...