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Updated: May 17, 2026

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example
Published on: November 18, 2015
Enantioselective formation of substituted 3,4-dihydrocoumarins by a multicatalytic one-pot process
Christian Borch Jacobsen1, Łukasz Albrecht, Jonas Udmark
1Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark.
Abstract:
The formation of optically active 3,4-dihydrocoumarins is presented by merging aminocatalysis with an N-heterocyclic carbene-catalyzed internal redox reaction. The products are formed in good to excellent yields and in general with excellent enantioselectivities. Moreover, the developed procedure demonstrates the potential of enantioselective, multicatalytic sequences. By employing an enantiopure aminocatalyst in the enantiodifferentiating step, the challenges related to achieving high stereoinductions by deployment of optically active NHC-catalysts can be circumvented.
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