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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Maternal depression and perception of teratogenicity
1The Motherisk Program, Hospital for Sick Children; Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada.
Summary
Maternal depression significantly impacts the perception of medication risks during pregnancy, potentially leading to harmful decisions. Addressing depression and providing accurate teratogenic risk counseling can reduce fear and prevent unnecessary pregnancy terminations.
Area of Science:
- Obstetrics and Gynecology
- Psychiatry
- Pharmacology
Background:
- Pregnancy exposures to medications and conditions are common.
- Most exposures do not increase congenital malformation risks.
- Misperceptions of teratogenic risks are prevalent and can lead to poor decisions.
Purpose of the Study:
- To explore the influence of maternal perceptions on pregnancy decisions.
- To investigate the role of maternal depressive symptomatology in teratogenic risk perception.
- To highlight the importance of accurate counseling and mental health support.
Main Methods:
- Review of existing literature on pregnancy exposures and risk perception.
- Analysis of factors influencing maternal decision-making during pregnancy.
- Discussion of the impact of emotional well-being on risk assessment.
Main Results:
- High perceived teratogenic risk can lead to therapy discontinuation or pregnancy termination.
- Maternal depression significantly distorts the perception of teratogenic risks.
- Informed decision-making is compromised by emotional distress.
Conclusions:
- Screening for and treating maternal depression is crucial.
- Accurate teratology counseling services can mitigate unnecessary fears.
- Interventions can reduce unwarranted pregnancy terminations due to risk misperceptions.
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