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Updated: May 17, 2026
Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
Published on: September 25, 2019
[Sequential evaluation of brain lesions using functional magnetic resonance imaging in patients with Leigh syndrome]
Zhiye Chen1, Jinfeng Li, Xin Lou
1Department of Radiology, Chinese PLA General Hospital, Beijing, China. yyqf@hotmail.com
Objective:
To investigate the value of functional magnetic resonance imaging (MRI) in sequential evaluation of patients with Leigh syndrome.
Methods:
Two patients with Leigh syndrome underwent diffusion weighted imaging (DWI), perfusion weighted imaging (PWI) and proton magnetic resonance spectroscopy ((1)H-MRS).
Results:
The brain lesions showed hyperintensity on DWI, lactate doublet peak on MRS and hyperperfusion in the patients at baseline, and maintained a hyperintensity on DWI and hyperperfusion in the absence of lactate doublet peak on MRS at follow-up 1 year later. DWI still revealed persistent hyperintensity in the brain lesions in one patient 2 years later.
Conclusion:
Functional MRI can sensitively highlight the characteristics of brain lesions in patients with Leigh syndrome, and can therefore be used to evaluate the sequential changes of the brain lesions.
