Dissecting causal relationships between dietary factors and intracerebral hemorrhage: A Mendelian randomization study

Intracerebral hemorrhage (ICH) is a severe and often fatal brain disorder. Despite the recognition of dietary adjustments as a preventive measure, there is a need for well-designed studies to investigate the dietary factors of ICH patients. We employed Mendelian randomization to explore the relationship between 35 dietary factors (exposures) and ICH (outcome). We applied several statistical methods, including inverse variance weighted, weighted median, Mendelian randomization-Egger regression, simple mode, and weighted mode. Furthermore, sensitivity analyses were conducted to ensure the robustness of our findings. Our study suggested that hot drink temperature (OR: 0.39, P = .037) and fresh fruit intake (OR: 0.389, P = .048) could potentially reduce the risk of ICH. Additionally, although a suggestively increased risk of ICH was observed with cooked vegetable intake (OR: 4.493, P = .036), the wide confidence interval (1.107-18.246) reflects imprecision in the estimate, and further research is needed to clarify this association. These findings provide novel dietary intervention strategies and insights for preventing ICH, holding the potential to inform more targeted health guidance recommendations.