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Neurologic disorders incidence in HIV+ vs HIV- men: Multicenter AIDS Cohort Study, 1996-2011

Farrah J Mateen1, Russell T Shinohara, Marco Carone

  • 1Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA.

Neurology
|October 19, 2012
PubMed

Insights

Men with HIV on highly active antiretroviral therapy (HAART) experience more neurologic disorders at younger ages than HIV-negative men. This study highlights increased risks for infections, dementia, seizures, and peripheral nerve issues.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Public Health

Background:

  • The advent of highly active antiretroviral therapy (HAART) has transformed HIV management.
  • Understanding the long-term impact of HIV on the nervous system in the HAART era is crucial.

Purpose of the Study:

  • To investigate the incidence and patterns of neurologic disorders in HIV-positive men compared to HIV-negative men.
  • To analyze these differences within the context of HAART treatment.

Main Methods:

  • A prospective study of men who have sex with men (MSM) was conducted.
  • Comparison of neurologic diagnoses incidence and categories between HIV-positive and HIV-negative participants during the HAART era (1996-2011).

Main Results:

  • HIV-positive men on HAART developed neurologic diagnoses at a significantly younger median age (48 years) than HIV-negative men (57 years).
  • Higher incidence rates of neurologic disorders were observed across all age groups in HIV-positive men.
  • Specific conditions like nervous system infections, dementia, seizures/epilepsy, and peripheral nervous system disorders were more prevalent in the HIV-positive group.

Conclusions:

  • HIV-positive men on HAART exhibit a greater burden of neurologic disease compared to their HIV-negative counterparts.
  • Neurologic conditions manifest at earlier ages in HIV-positive individuals undergoing HAART.
  • These findings underscore the need for continued surveillance and management of neurologic complications in the HIV-positive population.
Abstract

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