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The "Aging Males' Symptoms" Scale (AMS): predictive value for lowered circulating androgens
Friedemann Zengerling1, Andres Jan Schrader, Marcus Victor Cronauer
1Department of Urology, Ulm University Medical Center, Ulm, Germany. friedemann.zengerling@uniklinik-ulm.de
Summary
The Aging Males' Symptoms Questionnaire shows some correlation with low testosterone but lacks sufficient diagnostic efficiency for predicting hypogonadism in men.
Area of Science:
- Andrology
- Endocrinology
- Geriatrics
Background:
- Male climacteric symptoms are often linked to age-related androgen decline.
- The Aging Males' Symptoms (AMS) Questionnaire assesses these symptoms.
- This study investigates the link between AMS scores and androgen levels.
Purpose of the Study:
- To evaluate the relationship between climacteric symptoms and circulating androgen levels.
- To determine the diagnostic efficiency of the AMS Questionnaire for hypogonadism.
Main Methods:
- 146 ambulatory men (27-85 years) completed the AMS Questionnaire.
- Serum total testosterone (tT) and SHBG were measured.
- Free testosterone (fT) was calculated; pathological thresholds were defined.
Main Results:
- 25% of men had low tT, and 24.5% had low fT.
- 45.2% of men scored pathologically on the AMS Questionnaire.
- The AMS Questionnaire showed moderate sensitivity but limited specificity for predicting low tT; however, specific subscores correlated with low tT and fT.
Conclusions:
- The AMS Questionnaire, as a whole, does not provide sufficient diagnostic efficiency for predicting hypogonadism.
- Specific AMS subscores show significant correlations with reduced testosterone levels.
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