Mapping the spread of methamphetamine abuse in California from 1995 to 2008

Paul J Gruenewald1, William R Ponicki, Lillian G Remer

  • 1Prevention Research Center, Pacific Institute for Research and Evaluation, Berkeley, CA 94704, USA. paul@prev.org

Abstract

Insights

Methamphetamine abuse and dependence (MA) in California grew exponentially, exhibiting characteristics of a drug epidemic. This epidemic spread rapidly, particularly among low-income White and Hispanic populations outside urban centers.

Area of Science:

  • Epidemiology
  • Public Health
  • Substance Abuse Research

Background:

  • Methamphetamine abuse and dependence (MA) incidence in California hospitals surged 13-fold between 1983 and 2008.
  • The rapid increase prompted an investigation into whether this trend represented a drug epidemic.

Purpose of the Study:

  • To assess if the escalating incidence of methamphetamine abuse and dependence (MA) in California aligns with the characteristics of a drug epidemic.
  • To identify demographic and environmental factors associated with the spatial spread of MA.

Main Methods:

  • Geocoding of MA hospital discharges to residential zip codes from 1995-2008.
  • Utilizing Bayesian Poisson conditional autoregressive models to analyze relationships between MA incidence, population, and environmental factors.
  • Accounting for small area effects, spatial misalignment, and assessing contagion between geographic areas.

Main Results:

  • MA incidence demonstrated exponential growth in three distinct phases, interspersed with legislative interventions targeting precursor access.
  • Annual MA growth averaged 17% from 1999 to 2008.
  • Higher MA rates were observed in areas with significant low-income White and Hispanic populations, smaller households, and robust highway connectivity. Spatial autocorrelation explained approximately 80% of the model's error variance.

Conclusions:

  • From 1995 to 2008, methamphetamine abuse and dependence (MA) in California displayed epidemic-like growth and spatial diffusion patterns.
  • The epidemic spread most rapidly through low-income White and Hispanic communities situated in non-urbanized regions.

Related Concept Videos

Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
Drug Dependence01:17

Drug Dependence

Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
Drug Control Governance: Regulatory Bodies and Their Impact01:03

Drug Control Governance: Regulatory Bodies and Their Impact

Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with a...