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Angiotensin-converting enzyme I/D polymorphism and the risk of thoracic aortic dissection in Chinese Han population

Quanmin Jing1, Xiaozeng Wang, Yingyan Ma

  • 1Cardiovascular Research Institute and Department of Cardiology, Shenyang Northern Hospital, 83 Wenhua Road, Shenyang, China.

Molecular Biology Reports
|October 20, 2012
PubMed

Insights

The I/D polymorphism of the angiotensin-converting enzyme (ACE) gene is associated with an increased risk of thoracic aortic dissection (TAD). This finding suggests ACE gene variations may contribute to TAD development in the Chinese Han population.

Area of Science:

  • Cardiovascular Genetics
  • Molecular Biology
  • Epidemiology

Background:

  • Thoracic aortic dissection (TAD) is a life-threatening cardiovascular condition with a suspected genetic component.
  • The renin-angiotensin system is implicated in the development of aortic diseases.

Purpose of the Study:

  • To investigate the association between the angiotensin-converting enzyme (ACE) I/D polymorphism and the risk of TAD.
  • To evaluate the ACE I/D polymorphism's role in the pathogenesis of TAD within the Chinese Han population.

Main Methods:

  • A hospital-based case-control study was conducted.
  • 161 TAD patients and 256 control subjects were recruited.
  • ACE I/D polymorphism genotyping was performed using polymerase chain reaction (PCR).

Main Results:

  • A significant difference in ACE I/D genotype distribution was observed between TAD patients and controls.
  • Patients with TAD showed a higher frequency of the DD genotype and the D allele of the ACE gene.
  • Multivariate logistic regression revealed a significant association between ACE I/D polymorphism and TAD susceptibility (OR 2.14, P=0.001).

Conclusions:

  • The ACE I/D polymorphism is identified as a potential risk factor for thoracic aortic dissection.
  • Further large-scale population-based studies are warranted to validate these findings and confirm the association.

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