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Related Concept Videos

Urine Studies I: Urinalysis01:29

Urine Studies I: Urinalysis

Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...

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Related Experiment Video

Updated: May 17, 2026

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril
10:02

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

Published on: October 3, 2020

A Hydrogel Sensing Pathological Urate Concentrations.

Christian Geraths1, Erik H Christen1, Wilfried Weber2

  • 1Faculty of Biology and BIOSS Center for Biological Signalling Studies, University of Freiburg, Schänzlestrasse 18, 79104 Freiburg, Germany.

Macromolecular Rapid Communications
|October 20, 2012
PubMed
Summary
This summary is machine-generated.

This study presents a novel hydrogel that dissolves when detecting high urate levels, offering a new approach for gouty arthritis treatment. This metabolite-responsive material shows promise for targeted drug delivery in metabolic diseases.

Keywords:
DNA-protein interactionbiomaterialgoutrepressor proteinstimuli-sensitive polymers

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Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins
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Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins

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Last Updated: May 17, 2026

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril
10:02

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

Published on: October 3, 2020

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins
10:05

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins

Published on: August 7, 2014

Area of Science:

  • Biomaterials Science
  • Biochemistry
  • Drug Delivery

Background:

  • Metabolic diseases require advanced therapeutic strategies.
  • Metabolite-responsive hydrogels can deliver targeted treatments.
  • Urate accumulation causes gouty arthritis.

Purpose of the Study:

  • To develop a hydrogel capable of detecting and responding to pathological urate concentrations.
  • To create a smart material for potential gouty arthritis management.

Main Methods:

  • Synthesized a hydrogel by grafting a urate repressor protein (HucR) onto polyacrylamide.
  • Crosslinked the protein-grafted polymer using a multimeric DNA sequence ([hucO]n).
  • Investigated hydrogel response to varying urate concentrations.

Main Results:

  • The hydrogel successfully discriminated between physiological and pathological urate levels.
  • Elevated urate concentrations caused HucR dissociation from the DNA crosslinker.
  • Dissociation led to hydrogel structural weakening and dissolution.

Conclusions:

  • The developed hydrogel acts as a urate-sensitive material.
  • This system demonstrates potential for localized urate detection and response.
  • The hydrogel's dissolution mechanism offers a novel approach for therapeutic intervention in metabolic disorders like gout.