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Updated: May 17, 2026

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
Published on: December 15, 2023
Case report: detection of a hepatitis B surface antigen variant emerging in an elderly patient after an ischemic
Alban Deroux1, Sylvie Larrat, Marie-Noelle Hilleret
1Virology Laboratory / UMI 3265 UJF-EMBL-CNRS, CHU Grenoble, Michallon Hospital, BP 217, 38043 Grenoble Cedex 9, France.
Abstract:
HBV reactivations are observed frequently in patients with past hepatitis B infection receiving cytotoxic and/or immunosuppressive chemotherapy for hemato-oncological malignancies or autoimmune diseases. Recent ischemic stroke was shown to induce immunodepression by misunderstood mechanisms. To our knowledge, the association between HBV reactivation and ischemic stroke has not been reported before. This study reports the case of an anti-HBs- and anti-HBc-positive patient who presented HBV reactivation in a context of recent ischemic stroke, with no other intercurrent iatrogenic phenomenon or usual immunosuppressive pathology.
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