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Related Concept Videos

Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction. It is...
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...
Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...

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Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy
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Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy

Published on: April 4, 2013

Modelling cell migration and adhesion during development.

Robin N Thompson1, Christian A Yates, Ruth E Baker

  • 1Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, UK. rnt22@cam.ac.uk

Bulletin of Mathematical Biology
|October 20, 2012
PubMed
Summary
This summary is machine-generated.

This study compares stochastic and deterministic models of cell migration, finding that while deterministic models approximate average behavior, individual stochastic simulations can reveal unique cell clustering not seen in the mean. This highlights the importance of stochasticity in understanding cell aggregation.

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Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy
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Area of Science:

  • Mathematical Biology
  • Developmental Biology
  • Computational Biology

Background:

  • Cell-cell adhesion is crucial for tissue formation during biological development.
  • Existing models of cell migration often simplify complex adhesion and volume-filling dynamics.

Purpose of the Study:

  • To extend and analyze a stochastic space-jump model of cell migration incorporating cell-cell adhesion and volume filling.
  • To compare the stochastic model with deterministic counterparts (stochastic mean equations and partial differential equations).
  • To investigate the model's ability to simulate differential adhesion and its application to growing domains.

Main Methods:

  • Analysis of a stochastic space-jump model for cell migration.
  • Comparison with two deterministic models: a system of stochastic mean equations and a non-linear partial differential equation.
  • Incorporation of a second cell species to explore differential adhesion and implementation on a growing domain.

Main Results:

  • Deterministic models generally show qualitative similarity to the mean behavior of multiple stochastic simulations.
  • Individual stochastic simulations can exhibit significant deviations from the mean, including cell clustering.
  • The model demonstrates potential for simulating differential adhesion and adapting to growing domains.

Conclusions:

  • Stochastic models are essential for capturing emergent behaviors like cell clustering that deterministic models may miss.
  • The extended model provides a versatile framework for studying cell migration dynamics, including differential adhesion.
  • A novel approach for modeling cell migration on growing domains was successfully presented.