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Updated: May 17, 2026

Fast Inspection of Quality of Indigo Naturalis by Multiple Light Scattering
Published on: August 18, 2023
Water-soluble cationic derivatives of indirubin, the active anticancer component from Indigo naturalis
Werner Ginzinger1, Alexander Egger, Gerhard Mühlgassner
1University of Vienna, Institute of Inorganic Chemistry, Währinger Str. 42, A-1090 Vienna, Austria.
Abstract:
To overcome the problem of poor aqueous solubility and bioavailability of indirubin-3-oximes, the compounds were modified by attaching a quaternary ammonium group at the oxime moiety. Exploring the prodrug concept, an oxime ester with acetyl-l-carnitine was prepared, and the rate of its hydrolysis was investigated to assess its suitability for clinical administration. In addition, the cytotoxic potency of new stable oxime ethers with a choline moiety and their influence on the cell cycle were tested in human cancer cell lines.
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