Related Experiment Video
Updated: May 17, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Concomitant herpetic and eosinophilic esophagitis--a causality dilemma
P Monsanto1, N Almeida, M A Cipriano
1Gastroenterology Department, Coimbra University Hospital, Coimbra University Hospital, Coimbra, Portugal. pedromonsanto@gmail.com
Herpetic esophagitis can cause dysphagia in young adults. A rare case in an immunocompetent patient revealed a subsequent diagnosis of eosinophilic esophagitis, suggesting a potential link between these conditions.
Area of Science:
- Gastroenterology
- Virology
- Immunology
Background:
- Eosinophilic esophagitis and herpetic esophagitis are distinct causes of dysphagia, particularly in young males.
- Herpetic esophagitis is uncommon in immunocompetent individuals.
Observation:
- A young, immunocompetent male presented with severe dysphagia due to herpes simplex virus esophagitis.
- Following resolution of herpetic esophagitis, further evaluation revealed eosinophilic esophagitis.
Findings:
- This case highlights a potential association between herpes simplex virus esophagitis and eosinophilic esophagitis in an immunocompetent host.
- The co-occurrence suggests possible shared or sequential pathophysiological mechanisms.
Implications:
- Further research is warranted to explore the relationship between viral infections and eosinophilic esophagitis.
- This finding may influence diagnostic approaches and treatment strategies for dysphagia in young adults.
Related Concept Videos
Esophageal Achalasia
Esophageal Strictures-I: Introduction
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Gastroesophageal Reflux Disease
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
Causality in Epidemiology
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...

