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Updated: May 17, 2026

A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
Venous malformations: Clinical course and management of vascular birthmark clinic cases
Michelle Y McRae1, Susan Adams, John Pereira
1Paediatric Dermatology, Sydney Children’s Hospital, Randwick, NSW, Australia. michelle_mcrae@hotmail.com
Insights
Venous malformations (VM) are uncommon birthmarks affecting children, often diagnosed late. Management requires a multidisciplinary team due to frequent complications and varied treatment needs.
Area of Science:
- Pediatric Vascular Anomalies
- Dermatology
- Radiology
Background:
- Venous malformations (VM) are rare congenital vascular anomalies with an incidence of 1-2 per 10,000 births.
- Early identification and characterization are crucial for effective management and research.
- Understanding the clinical spectrum and treatment outcomes is essential for improving patient care.
Purpose of the Study:
- To define the clinical characteristics of venous malformations in children.
- To outline the management strategies employed for pediatric VM.
- To establish a database for future research into venous malformations.
Main Methods:
- Retrospective chart review of pediatric patients with VM.
- Data collected from patients presenting to a Vascular Birth Mark clinic between 2000 and 2011.
- Inclusion of demographic, clinical, diagnostic, and treatment data.
Main Results:
- 128 pediatric patients were analyzed, with a majority being female and Caucasian.
- Lesions were often present at birth, with delayed diagnosis (average 65.9 months).
- Common sites included lower limbs and face; frequent complications included pain, thrombophlebitis, and bleeding, necessitating interventions like sclerotherapy and compression therapy.
Conclusions:
- Venous malformations frequently associate with other vascular anomalies and cause significant morbidity.
- A multidisciplinary approach involving various specialists is vital for optimal management.
- Specialized care is recommended for children with venous malformations.
Background/Objectives:
Venous malformations (VM) are an uncommon vascular malformation with an estimated incidence of 1-2 per 10 000 births. The aim was to define the clinical characteristics and management of children with VM and develop a database for future research.
Methods:
A retrospective chart review of all children presenting to the Vascular Birth Mark clinic with VM from 2000 to 2011.
Results:
In total 128 patients were included, of whom 59.4% were female, 78.1% were Caucasian and 56.3% resided in a metropolitan area. Most lesions were noted at birth (64.1%) with an average age when VM was first noticed of 17.1 months. The average age of definitive diagnosis was 65.9 months. Locations most frequently involved were the lower limb (41.4%), face (21.1%), trunk (17.2%) and upper limb (15.6%). The most commonly associated conditions were capillary malformation (28.9%) and lymphatic malformation (28.1%). Magnetic resonance imaging was used in the majority of patients (86.7%) to assess tissue distribution of the lesions. Skin and subcutaneous tissue (61.3%), muscle (49.5%) and joints (11.7%) were most commonly involved. Complications of VM resulted in morbidity in 68.8% of cases, most commonly pain (52.3%), thrombophlebitis (17.2%), bleeding (13.3%) and limb length discrepancy (13.3%). Intervention was employed in 68.0%, most often with sclerotherapy (61.8%), compression garments (43.0%), and endovascular laser (17.2%) and surgical management (13.3%).
Conclusions:
Given the frequent association of VM with other vascular lesions, considerable morbidity, and specialised treatment, a multidisciplinary approach to their management in childhood is important and should include dermatology, diagnostic and interventional radiology, haematology, paediatric surgery, physiotherapy and social services.
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