Related Experiment Video
Updated: May 17, 2026

09:38
Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)
Published on: September 5, 2025
Reprint of BMCL_19101
Theresa A Lansdell1, Sandra O'Reilly, Tracey Woolliscroft
1Department of Chemistry, Michigan State University, East Lansing, MI, USA.
Bioorganic & Medicinal Chemistry Letters
|October 23, 2012
Abstract:
The pathogenesis of rheumatoid arthritis is mainly driven by NF-κB-mediated production of cytokines, such as TNF-α. We report herein that the orally available imidazoline-based NF-κB inhibitor, TCH-013, was found to significantly reduce TNF-α signaling and attenuate collagen antibody induced arthritis in BALB/c mice.
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