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Presentation of celiac disease.
Norelle Rizkalla Reilly1, Alessio Fasano, Peter H R Green
1Department of Pediatrics, Celiac Disease Center, Columbia University, New York, NY 10032, USA.
Gastrointestinal Endoscopy Clinics of North America
|October 23, 2012
Summary
Celiac disease presentations are shifting from classic diarrhea to subtle symptoms like abdominal pain and growth issues, especially in children. Screening now targets at-risk groups, including family members and those with Down syndrome or autoimmune conditions.
Area of Science:
- Gastroenterology
- Pediatrics
- Internal Medicine
Background:
- The clinical presentation of celiac disease has evolved significantly over recent decades.
- Classic diarrheal symptoms are becoming less frequent in newly diagnosed patients.
Purpose of the Study:
- To describe the changing modes of presentation for celiac disease.
- To identify key symptoms and at-risk populations for celiac disease screening.
Main Methods:
- Retrospective analysis of patient presentation data.
- Review of diagnostic criteria and screening guidelines for celiac disease.
- Comparison of symptom prevalence over time.
Main Results:
- Pediatric celiac disease commonly presents with recurrent abdominal pain, growth issues, and in screening cohorts.
- Adult celiac disease manifestations include diarrhea, anemia, osteoporosis, and incidental findings during endoscopy.
- Screening efforts increasingly focus on relatives, individuals with Down syndrome, and those with autoimmune diseases.
Conclusions:
- Celiac disease diagnosis requires awareness of non-traditional presentations.
- Targeted screening in specific populations is crucial for early detection.
- The shift in presentation necessitates updated diagnostic and screening strategies.
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