Related Experiment Video
Updated: May 17, 2026
12:05
Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation
Published on: November 3, 2018
[Mastocytosis and eosinophilic leukemia: diagnostics and classification].
K Sotlar1, P Valent, H-P Horny
1Pathologisches Institut, Ludwig-Maximilians-Universität München, Thalkirchner Str 36, 80337 München, Deutschland.
Der Pathologe
|October 23, 2012
Summary
Mastocytosis and eosinophilic neoplasms are rare bone marrow diseases that pose diagnostic challenges. Differentiating indolent from aggressive forms is crucial for prognosis, especially when eosinophils are involved.
Area of Science:
- Hematopathology
- Oncology
- Rare Diseases
Context:
- Mastocytosis and myeloid eosinophilic neoplasms are rare bone marrow disorders.
- Diagnostic challenges arise from compact mast cell infiltrates (mastocytosis) and eosinophilic granulocytes (myeloid eosinophilic neoplasms).
- Both disease groups encompass diverse entities defined by WHO criteria, requiring careful differentiation.
Purpose:
- To highlight the diagnostic complexities in mastocytosis and myeloid eosinophilic neoplasms.
- To differentiate between reactive and neoplastic eosinophilia in systemic mastocytosis (SM).
- To discuss the overlap and diagnostic criteria for SM with associated non-mastocytic hematological neoplasms (SM-AHNMD) and myeloproliferative neoplasms with eosinophilia (MPN-eo).
Summary:
- Systemic mastocytosis (SM) diagnosis and prognosis depend on differentiating indolent from aggressive forms.
- Indolent SM may show reactive eosinophilia (SM-eo), while aggressive forms, particularly SM-AHNMD like SM with chronic eosinophilic leukemia (SM-CEL), often feature neoplastic eosinophils.
- Aberrant mast cells in eosinophilic neoplasms are rare, seen in MPN-eo with PDGFR anomalies, indicating the need for WHO classification updates.
Impact:
- Improved diagnostic accuracy for rare bone marrow neoplasms.
- Enhanced understanding of the role and origin of eosinophils in mastocytosis and related disorders.
- Informs potential revisions to the WHO classification for eosinophilic leukemias and related neoplasms.
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