Related Experiment Video
Updated: May 17, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
Human leukocyte antigen DQ2.2 and celiac disease
Amani Mubarak1, Eric Spierings, Victorien Wolters
1Department of Pediatric Gastroenterology, University Medical Center Utrecht, Utrecht, The Netherlands. A.Mubarak@umcutrecht.nl
Abstract:
Patients with celiac disease (CD) lacking both human leukocyte antigen (HLA)-DQ2.5 in cis (DQA1*05:01, DQB1*02:01) or trans (DQA1*05:05, DQB1*02:02) configuration and HLA-DQ8 (DQA1*03:01, DQB1*03:02) are considered to be rare. Therefore, absence of these genotypes is commonly used to exclude the diagnosis of CD. To investigate whether this approach is justified, the HLA-distribution in 155 children with CD was studied. A total of 139 (89.7%) patients carried HLA-DQ2.5. Of the remaining patients, 7 (4.5%) carried HLA-DQ8. Interestingly, the 9 (5.8%) patients lacking HLA-DQ2.5 and HLA-DQ8 carried HLA-DQA1*02:01 and -DQB1*02:02 (HLA-DQ2.2). Therefore, HLA-DQ2.2 should be included as an important HLA-type related to CD.
Related Concept Videos
Antigens Involved in Adaptive Immunity
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Inflammatory Bowel Disease III: Crohn's Disease
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
Type I Diabetes II: Pathophysiology

