A decade of EEG Theta/Beta Ratio Research in ADHD: a meta-analysis
Martijn Arns1, C Keith Conners, Helena C Kraemer
1Research Institute Brainclinics, Nijmegen, Netherlands. martijn@brainclinics.com
Objective:
Many EEG studies have reported that ADHD is characterized by elevated Theta/Beta ratio (TBR). In this study we conducted a meta-analysis on the TBR in ADHD.
Method:
TBR data during Eyes Open from location Cz were analyzed from children/adolescents 6-18 years of age with and without ADHD.
Results:
Nine studies were identified with a total of 1253 children/adolescents with and 517 without ADHD. The grand-mean effect size (ES) for the 6-13 year-olds was 0.75 and for the 6-18 year-olds was 0.62. However the test for heterogeneity remained significant; therefore these ESs are misleading and considered an overestimation. Post-hoc analysis found a decreasing difference in TBR across years, explained by an increasing TBR for the non-ADHD groups.
Conclusion:
Excessive TBR cannot be considered a reliable diagnostic measure of ADHD, however a substantial sub-group of ADHD patients do deviate on this measure and TBR has prognostic value in this sub-group, warranting its use as a prognostic measure rather than a diagnostic measure.
