Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Temporal assessment of disparities in California COVID-19 mortality by industry: a population-based retrospective cohort study.

Annals of epidemiology·2023
Same author

COVID-19 Outbreaks and Mortality Among Public Transportation Workers - California, January 2020-May 2022.

MMWR. Morbidity and mortality weekly report·2022
Same author

Workplaces Most Affected by COVID-19 Outbreaks in California, January 2020-August 2021.

American journal of public health·2022
Same author

Disparities in COVID-19 fatalities among working Californians.

PloS one·2022
Same author

Severe Acute Respiratory Syndrome Coronavirus 2 and Respiratory Virus Sentinel Surveillance, California, USA, May 10, 2020-June 12, 2021.

Emerging infectious diseases·2021
Same author

Insight into hepatitis B prevalence and risk factors among Vietnamese Americans: a cross-sectional analysis of data from a community-based screening program.

BMJ open·2019
Same journal

Tracking Synthetic Adhesins on Bacterial Surfaces with Immunofluorescence Microscopy.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Post-Selection Methods for Analyzing mRNA Display Selections and Optimization of Hits.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

High-Performance Computing in Tandem Mass Spectrometry (MS/MS) Peptide Identification.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Engineering and Adapting Disulfide-Containing Proteins to Enable Intracellular Functionality.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

AI-Driven Protein Research: From Prediction to Design.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Methods for the In Vitro Selection of Protein and Peptide Libraries Using mRNA Display.

Methods in molecular biology (Clifton, N.J.)·2026
See all related articles

Related Experiment Video

Updated: May 17, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

Biomarkers.

Harmony Larson1, Elena Chan, Sucha Sudarsanam

  • 1Emiliem, Inc., San Francisco, CA, USA.

Methods in Molecular Biology (Clifton, N.J.)
|October 23, 2012
PubMed
Summary
This summary is machine-generated.

Biomarkers indicate biological processes or responses to chemicals. This research explores computational methods to discover new toxicity biomarkers from animal data and protein targets, aiding risk assessment and disease prediction.

More Related Videos

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

Related Experiment Videos

Last Updated: May 17, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

Area of Science:

  • Environmental health
  • Toxicology
  • Computational biology

Background:

  • Biomarkers are crucial for assessing biological processes, therapeutic responses, and environmental hazards.
  • Identifying new biomarkers for chemical toxicity is essential for risk assessment and human health protection.
  • Current methods involve animal models, human studies, and biobanked samples.

Purpose of the Study:

  • To explore computational approaches for discovering and inferring biomarkers.
  • To identify molecular targets of chemicals and their associated biological pathways.
  • To provide examples of biomarker discovery using toxicogenomics and protein target identification.

Main Methods:

  • Utilizing computational methods to predict molecular targets of chemicals.
  • Associating identified molecular targets with perturbed biological pathways.
  • Inferring potential human biomarkers from animal toxicogenomics data.
  • Identifying protein targets computationally and linking them to drug interactions or disease risk.

Main Results:

  • Demonstrated the feasibility of inferring human biomarkers from animal toxicogenomics data.
  • Successfully identified protein targets computationally.
  • Linked protein targets to potential drug interactions and increased risk for certain human diseases.

Conclusions:

  • Computational approaches are valuable for discovering and inferring biomarkers for chemical toxicity.
  • Identifying molecular targets and perturbed pathways is key to biomarker discovery.
  • These methods can aid in predicting drug interactions and disease risks, improving environmental and health risk assessments.