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Primary orbital non-Hodgkin's lymphoma
Sonal Amit1, Neetu Purwar, Asha Agarwal
1Department of Pathology, GSVM Medical College, Kanpur, Uttar Pradesh, India. drsonalamit@gmail.com
BMJ Case Reports
|October 23, 2012
Summary
This case study highlights an extremely rare instance of peripheral T-cell lymphoma, a type of non-Hodgkin's lymphoma, presenting as an aggressive orbital mass in a child. Early diagnosis and understanding of such rare presentations are crucial.
Area of Science:
- Oncology
- Ophthalmology
- Pathology
Background:
- Non-Hodgkin's lymphoma (NHL) can present in extranodal sites in about 25% of cases.
- Extranodal lymphoma in the head and neck region is exceptionally uncommon.
Observation:
- A 6-year-old girl presented with a medial canthus mass causing proptosis and lagophthalmos.
- CT revealed an extraconcal orbital mass with significant destruction of surrounding orbital tissues.
Findings:
- Histopathology showed a polymorphous population of atypical lymphoid cells, plasma cells, eosinophils, and vascular proliferation.
- Immunohistochemistry confirmed the diagnosis as peripheral T-cell lymphoma, a rare subtype of NHL.
Implications:
- This case underscores the rarity of orbital NHL and its aggressive nature in pediatric patients.
- Highlights the importance of considering rare differential diagnoses in pediatric orbital masses.
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