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Updated: May 17, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

HIV-associated multicentric Castleman's disease.

Fauzia de Fátima Naime¹, Felipe Fakhouri, Carlos Saraiva Martins

¹Instituto Paulista de Cancerologia, ; Conjunto Hospitalar do Mandaqui, ; Instituto do Câncer Arnaldo Vieira de Carvalho, São Paulo, Brazil.

|October 23, 2012

Summary

Multicentric Castleman's disease (MCD) is a rare disorder often seen in HIV patients. This case highlights a 32-year-old man with HIV and Kaposi's sarcoma, emphasizing diagnostic and treatment considerations for MCD.

Keywords:

Castleman's disease HIV Kaposi's sarcoma human herpes virus-8 rituximab.

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Last Updated: May 17, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

Area of Science:

Hematology
Oncology
Infectious Diseases

Background:

Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder.
MCD is more prevalent in individuals with HIV infection, often presenting with systemic symptoms and a poor prognosis.
Co-occurrence with Kaposi's sarcoma is noted in HIV-positive patients.

Purpose of the Study:

To present a case of Multicentric Castleman's disease in a 32-year-old male with HIV disease and Kaposi's sarcoma.
To discuss the diagnostic confirmation of MCD via biopsy.
To review current and emerging systemic treatment strategies for MCD.

Main Methods:

Case report presentation.
Biopsy for histopathological diagnosis of Castleman's disease.
Review of systemic treatment modalities for MCD.

Main Results:

A 32-year-old male with HIV disease, Kaposi's sarcoma, lymphadenopathy, fever, and hemolytic anemia was diagnosed with MCD.
Diagnosis was confirmed through biopsy.
Treatment options discussed include chemotherapy, antiviral therapy, HAART, and monoclonal antibodies (anti-IL6, anti-CD20).

Conclusions:

Multicentric Castleman's disease in HIV-infected individuals presents with significant systemic symptoms.
Diagnosis relies on biopsy, and treatment strategies are evolving.
Emerging therapies like monoclonal antibodies offer new avenues for managing this rare condition.