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In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice

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Contrast-enhanced MR imaging in neuroimaging.

Bum-soo Kim¹, Juan E Gutierrez

¹Department of Radiology, The Catholic University of Korea, Seoul, Korea.

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|October 24, 2012

Summary

Magnetic Resonance Imaging (MRI) with gadolinium-based contrast agents (GBCAs) is crucial for diagnosing central nervous system lesions. Unenhanced and GBCA-enhanced MRI is the gold standard for detecting and outlining brain and spinal lesions.

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Area of Science:

Radiology
Neurology
Medical Imaging

Background:

Magnetic Resonance Imaging (MRI) is a vital diagnostic tool.
Gadolinium-based contrast agents (GBCAs) enhance MRI visualization.
GBCAs have been used for over two decades in central nervous system (CNS) imaging.

Purpose of the Study:

To highlight the importance of MRI with and without GBCAs.
To emphasize the role of contrast-enhanced MRI in CNS lesion characterization.
To establish the gold standard for noninvasive lesion detection in the CNS.

Main Methods:

Utilizing both unenhanced and GBCA-enhanced MR imaging techniques.
Applying MRI for the definition of normal anatomy.
Characterizing various types of lesions within the central nervous system.

Main Results:

GBCA-enhanced MRI significantly aids in defining and characterizing CNS lesions.
The combination of unenhanced and enhanced MRI represents the clinical gold standard.
MRI demonstrates high predictive value in ruling out neoplasms and inflammatory conditions.

Conclusions:

MRI with GBCAs is essential for CNS lesion evaluation.
Contrast-enhanced MRI is a reliable method for detecting and delineating intracranial and spinal lesions.
MRI plays a key role in excluding serious neurological conditions noninvasively.