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Ketorolac-associated renal morbidity: risk factors in cardiac surgical infants

Brady S Moffett1, Antonio Cabrera

  • 1Department of Pharmacy, Texas Children's Hospital, Houston, Texas 7703, USA. bsmoffet@texaschildrens.org

Cardiology in the Young
|October 24, 2012
PubMed

Insights

Ketorolac use after heart surgery in infants may increase acute kidney injury risk. Combining ketorolac with aspirin appears particularly risky for kidney health in these young patients.

Area of Science:

  • Pediatric Surgery
  • Nephrology
  • Pharmacology

Background:

  • Acute kidney injury (AKI) is a concern in infants post-cardiac surgery.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) like ketorolac are sometimes used for pain management.
  • Understanding risk factors for AKI in this population is crucial.

Purpose of the Study:

  • To identify risk factors for AKI in infants receiving ketorolac after cardiac surgery.
  • To compare patients with significant serum creatinine increase to controls.

Main Methods:

  • Retrospective case-control study design.
  • Identified infants with >= 50% increase in serum creatinine post-ketorolac.
  • Matched cases with age-matched controls (< 50% creatinine increase).

Main Results:

  • Significant differences observed in primary surgical procedure type.
  • Baseline serum creatinine levels varied between groups.
  • Concomitant aspirin use was a notable difference.

Conclusions:

  • Concomitant aspirin use with ketorolac is associated with increased renal morbidity.
  • This combination poses a risk for young infants undergoing cardiac surgery.
  • Further research may be warranted to confirm these findings and guide clinical practice.

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